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1Essential

Vitamin K2

Also sold as MK-7, MK-4, menaquinone

Directs calcium into bone rather than arteries. Sparse outside natto and aged cheese.

TrustedSupp Tier System™ · Tier 1Take persistently
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

58/100Moderate
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: bone density markers; cardiovascular claims are weaker.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Ongoing alongside vitamin D, since the dietary sources are genuinely rare in most diets.

Who it's actually for

Anyone supplementing vitamin D long-term, and people managing bone density.

Safe upper limit

Unverified
None established
No formal upper limit, but the warfarin interaction is the hard constraint, not toxicity. No EFSA/NIH UL exists for vitamin K generally, but this needs direct confirmation. The warfarin interaction is the more load-bearing fact here and needs its own check.
No source or citation attached yet.

Interactions to know about

Other supplements:

Run your full list through the interaction check.

Practical notes

  • MK-7 stays in the blood far longer than MK-4 — once daily is enough.
  • Take with fat.
  • If you are on warfarin, do not start or stop this without telling your prescriber.