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Urolithin A

Also sold as Mitopure, UA

A gut-microbe metabolite of pomegranate and walnut compounds, marketed for mitochondrial and muscle health — early human data, with a clean safety record so far.

TrustedSupp Tier System™ · Tier 4Take by choice, or not at all

Evidence strength

45/100Limited
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: modest improvements in muscle endurance and mitochondrial markers in small, mostly manufacturer-funded trials.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Course-based while evaluating effect; long-term continuous use has not been studied.

Who it's actually for

Older adults interested in muscle endurance, with realistic expectations about early-stage evidence.

Safe upper limit

Unverified
No formal upper limit; trials used 250–1,000 mg daily for up to four months
Human trials report mild digestive upset at rates similar to placebo, with no liver, kidney, or hormonal signals. Safety beyond about four months of continuous use is not well characterised.
No source or citation attached yet.

Interactions to know about

No commonly documented medication clashes in our data. That is not the same as none existing.

Run your full list through the interaction check.

Practical notes

  • Only some people's gut bacteria make urolithin A from pomegranate — supplements bypass that, which is the main selling point.
  • Most human trials are manufacturer-funded; independent replication is limited.
  • With active cancer, check with your oncologist first — a theoretical rather than proven concern.