← Back
4Optional

Spermidine

Also sold as Wheat germ extract

Autophagy interest, minimal human evidence so far.

TrustedSupp Tier System™ · Tier 4Take by choice, or not at all

Evidence strength

20/100Weak
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: autophagy markers; no human health outcome data.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Not established.

Who it's actually for

People comfortable funding an experiment on themselves.

Safe upper limit

Unverified
No formal limit; 1–6 mg daily in trials
Short-term safety looks acceptable. No long-term human data exists.
No source or citation attached yet.

Interactions to know about

No commonly documented medication clashes in our data. That is not the same as none existing.

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Wheat germ, aged cheese and natto are dietary sources.
  • Autophagy markers are not health outcomes.