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3Medicinal

Red clover

Also sold as Trifolium pratense, red clover isoflavones

A source of isoflavones used for menopausal hot flushes — overall trial results are weak.

TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

22/100Weak
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: menopausal hot flushes — reviews find little consistent benefit.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Up to about 12 months in trials; reassess regularly.

Who it's actually for

Women exploring hot-flush relief without hormone therapy, after discussing options with a clinician.

Safe upper limit

Unverified
No formal upper limit; 40–80 mg isoflavones daily in trials
Generally well tolerated short term. Its oestrogen-like activity is the reason for caution with hormone-sensitive conditions and hormone therapy. It may also have mild blood-thinning effects.
No source or citation attached yet.

Interactions to know about

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Reviews find little consistent benefit over placebo for hot flushes.
  • Avoid with hormone-sensitive cancers or while taking tamoxifen unless your oncologist agrees.
  • Not for use in pregnancy.