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1Essential

Prenatal folate

Also sold as Folic acid, 5-MTHF, prenatal

Started before conception and continued through the first trimester without exception.

TrustedSupp Tier System™ · Tier 1Take persistently
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

98/100Very strong
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: preventing neural tube defects — among the strongest evidence in nutrition.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

From at least one month before conception through the first trimester, and often throughout pregnancy.

Who it's actually for

Anyone who could become pregnant. Neural tube closure happens before most people know they're pregnant.

Safe upper limit

Unverified
1,000 mcg per day of supplemental folic acid
High supplemental folic acid can mask B12 deficiency while nerve damage progresses underneath.
No source or citation attached yet.

Interactions to know about

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Start before trying, not after a positive test.
  • Some conditions and medications require a much higher prescribed dose — ask.