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4Optional

NMN / NR

Also sold as Nicotinamide riboside, nicotinamide mononucleotide, NAD

Heavily marketed; human outcome data remains limited.

TrustedSupp Tier System™ · Tier 4Take by choice, or not at all
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

25/100Weak
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: raising NAD levels — which is not the same as a health outcome.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Unknown. There is no established course because there is no established benefit.

Who it's actually for

People comfortable funding an experiment on themselves.

Safe upper limit

Unverified
No formal limit; 250–1,000 mg daily in trials
Short-term safety looks acceptable. Long-term data does not exist. Regulatory status is in flux.
No source or citation attached yet.

Interactions to know about

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Raising NAD levels is well demonstrated; translating that into health outcomes is not.
  • Price per gram varies enormously for identical compounds.