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3Medicinal

MSM

Also sold as Methylsulfonylmethane

Used for joint pain and stiffness alongside other joint agents.

TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

42/100Limited
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: osteoarthritis pain in small short trials.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Twelve week trial, then reassess.

Who it's actually for

Osteoarthritis, usually stacked with glucosamine or chondroitin.

Safe upper limit

Unverified
No formal limit; 1.5–6 g daily in trials
Well tolerated. GI upset at higher doses.
No source or citation attached yet.

Interactions to know about

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Trials are small; effect sizes are modest.
  • Often bundled into joint formulas, so check for duplication.