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3Medicinal

Melatonin

Best for jet lag and shifted body clocks. Timing matters more than dose.

TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

82/100Strong
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: jet lag and delayed sleep phase; weaker for ordinary insomnia.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Short courses — days for jet lag, weeks for a shifted schedule. Not a nightly permanent aid without medical advice.

Who it's actually for

Jet lag, shift work, and delayed sleep phase. Less useful for classic insomnia.

Safe upper limit

Unverified
No formal limit; 0.5–3 mg is effective, and more is not better
Higher doses cause grogginess and vivid dreams without improving sleep. Long-term effects in children are not well established. Regulated as a supplement in North America but a prescription drug in the UK/EU — itself worth surfacing. No IOM-style UL exists; needs a clinical pharmacology source, not a nutrient fact sheet.
No source or citation attached yet.

Interactions to know about

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Take it two to three hours before your target bedtime, not at bedtime.
  • Start at 0.5 mg — most products are five to ten times stronger than needed.
  • Talk to a paediatrician before giving it to a child.