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3Medicinal

GABA

Also sold as Gamma-aminobutyric acid

Widely sold, but oral absorption into the brain is questionable.

TrustedSupp Tier System™ · Tier 3Take as a defined course

Evidence strength

25/100Weak
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: relaxation measures; the mechanism remains unresolved.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

No established course.

Who it's actually for

Limited justification given the blood-brain barrier problem.

Safe upper limit

Unverified
No formal limit; 100–3,000 mg daily in trials
Well tolerated, largely because much of it may not reach the brain.
No source or citation attached yet.

Interactions to know about

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Oral GABA crosses the blood-brain barrier poorly — any effect may be via the gut nervous system.
  • L-theanine has better support for the same goal.