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3Medicinal

DIM

Also sold as Diindolylmethane, indole-3-carbinol

Marketed for oestrogen metabolism; evidence remains thin.

TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.

Evidence strength

28/100Weak
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: altering oestrogen metabolite ratios; clinical outcomes are unproven.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Not established. Course-based at most.

Who it's actually for

Limited justification outside specific clinical guidance.

Safe upper limit

Unverified
No formal limit; 100–200 mg daily is typical
Alters oestrogen metabolism and induces drug-clearing enzymes. Can cause headaches and darkened urine.
No source or citation attached yet.

Interactions to know about

Run your full list through the interaction check.

Practical notes

  • Can reduce the effectiveness of hormonal contraception.
  • Cruciferous vegetables provide the precursor at food level.