TrustedSupp Tier System™ · Tier 3Take as a defined course
Check before you startThis one has documented interactions with medication classes where the consequences are serious. If you take any prescription medicine, run it past a pharmacist before starting.
Evidence strength
50/100Moderate
WEAKLIMITEDMODERATESTRONGVERY STRONG
What the evidence supports: low back pain and osteoarthritis in moderate-quality trials.
This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.
How long to take it
Short courses for pain flares.
Who it's actually for
Adults with low back or osteoarthritis pain.
Safe upper limit
Unverified
No formal limit; 50–100 mg harpagoside daily
Can increase stomach acid and worsen ulcers. Affects heart rhythm at high doses.