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3Medicinal

Collagen type II

Also sold as UC-II, undenatured collagen

Undenatured form studied specifically for joint comfort.

TrustedSupp Tier System™ · Tier 3Take as a defined course

Evidence strength

48/100Limited
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: knee joint comfort in mostly industry-funded trials.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Three to six month trial.

Who it's actually for

Knee osteoarthritis and exercise-related joint discomfort.

Safe upper limit

Unverified
No formal limit; 40 mg UC-II daily
Well tolerated.
No source or citation attached yet.

Interactions to know about

No commonly documented medication clashes in our data. That is not the same as none existing.

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Undenatured type II works by a different mechanism than collagen peptides — don't substitute one for the other.
  • Most trials are manufacturer-funded.