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2Corrective

Betaine

Also sold as TMG, trimethylglycine

Supports methylation alongside folate and B12 when homocysteine is high.

TrustedSupp Tier System™ · Tier 2Take until levels correct

Evidence strength

55/100Moderate
WEAKLIMITEDMODERATESTRONGVERY STRONG

What the evidence supports: lowering homocysteine; performance claims are weaker.

This scores how well-supported the claim above is — not how much benefit you personally would get. A high score on a narrow claim does not extend to everything the product is marketed for.

How long to take it

Course-based, guided by homocysteine testing.

Who it's actually for

People with elevated homocysteine, and some performance use.

Safe upper limit

Unverified
No formal limit; 2.5–6 g daily in trials
Can raise LDL cholesterol at higher doses. Fishy odour is possible.
No source or citation attached yet.

Interactions to know about

No commonly documented medication clashes in our data. That is not the same as none existing.

Other supplements:

Run your full list through the interaction check.

Practical notes

  • Watch lipids if you take it at performance doses.
  • Beetroot is the dietary source, hence the name.